Inhambane Airport is a 20km drive from Tofo. There are two flights a week from Maputo (Wed and Sun) with connections to Johannesburg, Cape Town, Lisbon and many more. 

You can drive to Tofo with any car. It is 500km (+/- 8 hrs) from Maputo, and 1000 km (+/- 15hrs) from Johannesburg or Durban 

There is a regular shuttle service from Johannesburg and Pretoria to Tofo and onward to Vilanculos.